Influence of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib: A Randomized Crossover Pharmacokinetic Study

Regorafenib exposure could potentially be influenced by an interaction with acid‐reducing drugs. In this crossover trial, patients were randomized into two sequence groups consisting of three phases: regorafenib intake alone, regorafenib with concomitant esomeprazole, and regorafenib with esomeprazo...

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Detalles Bibliográficos
Autores principales: de Man, Femke M., Hussaarts, Koen G.A.M., de With, Mirjam, Oomen‐de Hoop, Esther, de Bruijn, Peter, van Halteren, Henk K., van der Burg‐de Graauw, Nicole C.H.P., Eskens, Ferry A.L.M., van Gelder, Teun, van Leeuwen, Roelof W.F., Mathijssen, Ron H.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593619/
https://www.ncbi.nlm.nih.gov/pubmed/30570132
http://dx.doi.org/10.1002/cpt.1331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593619/
https://www.ncbi.nlm.nih.gov/pubmed/30570132
http://dx.doi.org/10.1002/cpt.1331

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