Cargando…

N‐methyl‐D‐aspartate receptor dysfunction by unmutated human antibodies against the NR1 subunit

Anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis related to autoantibody‐mediated synaptic dysfunction. Cerebrospinal fluid–derived human monoclonal NR1 autoantibodies showed low numbers of somatic hypermutations or were unmutated. These unexpected g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wenke, Nina Kerstin, Kreye, Jakob, Andrzejak, Ewa, van Casteren, Adriana, Leubner, Jonas, Murgueitio, Manuela S., Reincke, S. Momsen, Secker, Christopher, Schmidl, Lars, Geis, Christian, Ackermann, Frauke, Nikolaus, Marc, Garner, Craig C., Wardemann, Hedda, Wolber, Gerhard, Prüss, Harald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	Brief Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593665/ https://www.ncbi.nlm.nih.gov/pubmed/30843274 http://dx.doi.org/10.1002/ana.25460

Ejemplares similares

Do cross-reactive antibodies cause neuropathology in COVID-19?
por: Kreye, Jakob, et al.
Publicado: (2020)

Brain antibody sequence evaluation (BASE): an easy-to-use software for complete data analysis in single cell immunoglobulin cloning
por: Reincke, S. Momsen, et al.
Publicado: (2020)

Affinities of human NMDA receptor autoantibodies: implications for disease mechanisms and clinical diagnostics
por: Ly, Lam-Thanh, et al.
Publicado: (2018)

Differential Modes of Action of α1- and α1γ2-Autoantibodies Derived from Patients with GABA(A)R Encephalitis
por: van Casteren, Adriana C. M., et al.
Publicado: (2022)

Antigenic imprinting in SARS‐CoV‐2
por: Reincke, S. Momsen, et al.
Publicado: (2022)

Patient-Derived Anti-NMDAR Antibody Disinhibits Cortical Neuronal Networks through Dysfunction of Inhibitory Neuron Output
por: Andrzejak, Ewa, et al.
Publicado: (2022)

Vom Unmut zum Zorn
por: Ruhaltinger, Josef
Publicado: (2023)

Breiter Unmut über CERN-Ausstieg
Publicado: (2009)

Unmute the Organization Through Serious Play
por: Heldal, Frode, et al.
Publicado: (2021)

Encephalitis patient-derived monoclonal GABA(A) receptor antibodies cause epileptic seizures
por: Kreye, Jakob, et al.
Publicado: (2021)

Discovery of novel TLR modulators by Molecular Modeling and Virtual Screening
por: Murgueitio, Manuela S, et al.
Publicado: (2012)

How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein
por: Wahl, Ilka, et al.
Publicado: (2022)

Sterilizing immunity: Understanding COVID-19
por: Wahl, Ilka, et al.
Publicado: (2022)

Brain blood vessel autoantibodies in patients with NMDA and GABA(A) receptor encephalitis: identification of unconventional Myosin-X as target antigen
por: Li, Lucie Y., et al.
Publicado: (2023)

In silico virtual screening approaches for anti-viral drug discovery
por: Murgueitio, Manuela S., et al.
Publicado: (2012)

JAK2 unmutated erythrocytosis: current diagnostic approach and therapeutic views
por: Gangat, Naseema, et al.
Publicado: (2021)

NR1 and NR3B Composed Intranuclear N-methyl-d-aspartate Receptor Complexes in Human Melanoma Cells
por: Hajdú, Tibor, et al.
Publicado: (2018)

New markers for murine memory B cells that define mutated and unmutated subsets
por: Anderson, Shannon M., et al.
Publicado: (2007)

Differential Requirement for Protein Synthesis in Presynaptic Unmuting and Muting in Hippocampal Glutamate Terminals
por: Crawford, Devon C., et al.
Publicado: (2012)

IgA autoantibodies against native myelin basic protein in a patient with MS
por: Schumacher, Heike, et al.
Publicado: (2019)

Human Autoantibody Silencing by Immunoglobulin Light Chains
por: Wardemann, Hedda, et al.
Publicado: (2004)

Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut
por: Prüss, H., et al.
Publicado: (2015)

Unmutated Immunoglobulin M Can Protect Mice from Death by Influenza Virus Infection
por: Harada, Yuichi, et al.
Publicado: (2003)

Identification of Distinct Unmutated Chronic Lymphocytic Leukemia Subsets in Mice Based on Their T Cell Dependency
por: Pal Singh, Simar, et al.
Publicado: (2018)

Unmuting Medical Students’ Education: Utilizing Telemedicine During the COVID-19 Pandemic and Beyond
por: Iancu, Ariella Magen, et al.
Publicado: (2020)

BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib
por: Bonfiglio, Silvia, et al.
Publicado: (2023)

High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms
por: Franke, Christiana, et al.
Publicado: (2021)

B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen
por: Wardemann, Hedda, et al.
Publicado: (2002)

P1012: CHARACTERIZING JAK2 MUTATED AND UNMUTATED ERYTHROCYTOSIS: A CLINICAL AND GENETIC COMPARISON
por: Mee Hwang, Sang, et al.
Publicado: (2023)

Modulation of NR1 subunit of N-methyl-D-aspartate receptor by ovariectomy and passive avoidance learning
por: Taherianfard, Mahnaz, et al.
Publicado: (2012)

Direct high‐throughput amplification and sequencing of immunoglobulin genes from single human B cells
por: Murugan, Rajagopal, et al.
Publicado: (2015)

Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib
por: Guo, Ailin, et al.
Publicado: (2015)

Pseudo-Peritoneal Carcinomatosis Presentation of a Crystal-Storing Histiocytosis With an Unmutated Monoclonal κ Light Chain
por: Aline-Fardin, Aude, et al.
Publicado: (2015)

Double IGHV DNA gene rearrangements in CLL: influence of mixed-mutated and -unmutated rearrangements on outcomes in CLL
por: Heyman, B, et al.
Publicado: (2016)

Preferential use of unmutated immunoglobulin heavy variable region genes in Boxer dogs with chronic lymphocytic leukemia
por: Rout, Emily D., et al.
Publicado: (2018)

Role of long non-coding RNAs in disease progression of early stage unmutated chronic lymphocytic leukemia
por: Tschumper, Renee C., et al.
Publicado: (2019)

A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection
por: Liu, Hejun, et al.
Publicado: (2021)

sciReptor: analysis of single-cell level immunoglobulin repertoires
por: Imkeller, Katharina, et al.
Publicado: (2016)

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
por: Yuan, Meng, et al.
Publicado: (2021)

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
por: Yuan, Meng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e9lsr0t8r34rp1scmen7nvdjv7