A Cocktail Interaction Study Evaluating the Drug‐Drug Interaction Potential of the Perpetrator Drug ASP8477 at Multiple Ascending Dose Levels

ASP8477 (molecular weight 325.36 g/mol) is a fatty acid amide hydrolase inhibitor intended for the treatment of neuropathic pain. Results from in vitro studies indicated that ASP8477 is a direct inhibitor of cytochrome P450 (CYP) 2C8, 2C9, 2C19, 2D6, and 3A4 enzymes at expected efficacious concentra...

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Detalles Bibliográficos
Autores principales: Treijtel, Nicoline, Collins, Christiane, van Bruijnsvoort, Michel, Fuhr, Rainard, Ernault, Etienne, Gangaram‐Panday, Shanti, Passier, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593727/
https://www.ncbi.nlm.nih.gov/pubmed/30730615
http://dx.doi.org/10.1002/cpdd.660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593727/
https://www.ncbi.nlm.nih.gov/pubmed/30730615
http://dx.doi.org/10.1002/cpdd.660

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