Magnetic resonance imaging–guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease

OBJECTIVE: To understand the safety, putaminal coverage, and enzyme expression of adeno‐associated viral vector serotype‐2 encoding the complementary DNA for the enzyme, aromatic L‐amino acid decarboxylase (VY‐AADC01), delivered using novel intraoperative monitoring to optimize delivery. METHODS: Fi...

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Detalles Bibliográficos
Autores principales: Christine, Chadwick W., Bankiewicz, Krystof S., Van Laar, Amber D., Richardson, R. Mark, Ravina, Bernard, Kells, Adrian P., Boot, Brendon, Martin, Alastair J., Nutt, John, Thompson, Marin E., Larson, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593762/
https://www.ncbi.nlm.nih.gov/pubmed/30802998
http://dx.doi.org/10.1002/ana.25450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593762/
https://www.ncbi.nlm.nih.gov/pubmed/30802998
http://dx.doi.org/10.1002/ana.25450

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