Synthesis and Biological Evaluation of RGD and isoDGR–Monomethyl Auristatin Conjugates Targeting Integrin α(V)β(3)

This work reports the synthesis of a series of small‐molecule–drug conjugates containing the α(V)β(3)‐integrin ligand cyclo[DKP‐RGD] or cyclo[DKP‐isoDGR], a lysosomally cleavable Val‐Ala (VA) linker or an “uncleavable” version devoid of this sequence, and monomethyl auristatin E (MMAE) or F (MMAF) a...

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Detalles Bibliográficos
Autores principales: Raposo Moreira Dias, André, Bodero, Lizeth, Martins, Ana, Arosio, Daniela, Gazzola, Silvia, Belvisi, Laura, Pignataro, Luca, Steinkühler, Christian, Dal Corso, Alberto, Gennari, Cesare, Piarulli, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593765/
https://www.ncbi.nlm.nih.gov/pubmed/30840356
http://dx.doi.org/10.1002/cmdc.201900049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593765/
https://www.ncbi.nlm.nih.gov/pubmed/30840356
http://dx.doi.org/10.1002/cmdc.201900049

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