RNA polymerase pausing at a protein roadblock can enhance transcriptional interference by promoter occlusion

Convergent promoters exert transcriptional interference (TI) by several mechanisms including promoter occlusion, where elongating RNA polymerases (RNAPs) block access to a promoter. Here, we tested whether pausing of RNAPs by obstructive DNA‐bound proteins can enhance TI by promoter occlusion. Using...

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Detalles Bibliográficos
Autores principales: Hao, Nan, Crooks, Michael T., Palmer, Adam C., Dodd, Ian B., Shearwin, Keith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593788/
https://www.ncbi.nlm.nih.gov/pubmed/30892685
http://dx.doi.org/10.1002/1873-3468.13365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593788/
https://www.ncbi.nlm.nih.gov/pubmed/30892685
http://dx.doi.org/10.1002/1873-3468.13365

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