Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor

AAA+ proteins form asymmetric hexameric rings that hydrolyze ATP and thread substrate proteins through a central channel via mobile substrate-binding pore loops. Understanding how ATPase and threading activities are regulated and intertwined is key to understanding the AAA+ protein mechanism. We stu...

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Detalles Bibliográficos
Autores principales: Deville, Célia, Franke, Kamila, Mogk, Axel, Bukau, Bernd, Saibil, Helen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593972/
https://www.ncbi.nlm.nih.gov/pubmed/31216466
http://dx.doi.org/10.1016/j.celrep.2019.05.075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593972/
https://www.ncbi.nlm.nih.gov/pubmed/31216466
http://dx.doi.org/10.1016/j.celrep.2019.05.075

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