Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Adenylate-forming enzymes are a mechanistic superfamily that are involved in diverse biochemical pathways. They catalyze ATP-dependent activation of carboxylic acid substrates as reactive acyl adenylate (acyl-AMP) intermediates and subsequent coupling to various nucleophiles to generate ester, thioe...

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Detalles Bibliográficos
Autores principales: Lux, Michaelyn C., Standke, Lisa C., Tan, Derek S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Special Feature: Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594144/
https://www.ncbi.nlm.nih.gov/pubmed/30982830
http://dx.doi.org/10.1038/s41429-019-0171-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594144/
https://www.ncbi.nlm.nih.gov/pubmed/30982830
http://dx.doi.org/10.1038/s41429-019-0171-2

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