Ionisation bias undermines the use of matrix‐assisted laser desorption/ionisation for estimating peptide deamidation: Synthetic peptide studies demonstrate electrospray ionisation gives more reliable response ratios

RATIONALE: Although mass spectrometry (MS) is routinely used to determine deamination in peptide mixtures, the effects of the choice of ionisation source have not yet been investigated. In particular, matrix‐assisted laser desorption/ionisation (MALDI) has become a popular tool with which to measure...

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Detalles Bibliográficos
Autores principales: Simpson, Joanna P., Fascione, Martin, Bergström, Ed, Wilson, Julie, Collins, Matthew J., Penkman, Kirsty E.H., Thomas‐Oates, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594239/
https://www.ncbi.nlm.nih.gov/pubmed/30908787
http://dx.doi.org/10.1002/rcm.8441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594239/
https://www.ncbi.nlm.nih.gov/pubmed/30908787
http://dx.doi.org/10.1002/rcm.8441

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