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Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations

The devastating inherited disease cystic fibrosis (CF) is caused by mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel. The recent approval of the CFTR potentiator drug ivacaftor (Vx-770) for the treatment of CF patients has marked the advent of causative CF th...

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Detalles Bibliográficos
Autores principales: Csanády, László, Töröcsik, Beáta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594753/
https://www.ncbi.nlm.nih.gov/pubmed/31205003
http://dx.doi.org/10.7554/eLife.46450