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GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoproteins (TRLs) along capillaries, allowing the lipolyti...

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Detalles Bibliográficos
Autores principales: Hu, Xuchen, Matsumoto, Ken, Jung, Rachel S, Weston, Thomas A, Heizer, Patrick J, He, Cuiwen, Sandoval, Norma P, Allan, Christopher M, Tu, Yiping, Vinters, Harry V, Liau, Linda M, Ellison, Rochelle M, Morales, Jazmin E, Baufeld, Lynn J, Bayley, Nicholas A, He, Liqun, Betsholtz, Christer, Beigneux, Anne P, Nathanson, David A, Gerhardt, Holger, Young, Stephen G, Fong, Loren G, Jiang, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594755/
https://www.ncbi.nlm.nih.gov/pubmed/31169500
http://dx.doi.org/10.7554/eLife.47178