Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs

Many drug candidates fail therapeutic development because of poor aqueous solubility. We have conceived a computer-aided strategy to enable polymeric micelle-based delivery of poorly soluble drugs. We built models predicting both drug loading efficiency (LE) and loading capacity (LC) using novel des...

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Detalles Bibliográficos
Autores principales: Alves, Vinicius M., Hwang, Duhyeong, Muratov, Eugene, Sokolsky-Papkov, Marina, Varlamova, Ekaterina, Vinod, Natasha, Lim, Chaemin, Andrade, Carolina H., Tropsha, Alexander, Kabanov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594770/
https://www.ncbi.nlm.nih.gov/pubmed/31249867
http://dx.doi.org/10.1126/sciadv.aav9784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594770/
https://www.ncbi.nlm.nih.gov/pubmed/31249867
http://dx.doi.org/10.1126/sciadv.aav9784

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