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E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis

Cardiomyocyte apoptosis is a major cause of myocardial ischemia/reperfusion (MI/R) injury, in which the activation of the signal transducer and activator of transcription 1 (STAT1) plays an important role. The E3-ubiquitin ligase TRIM6 has been implicated in regulating STAT1 activity, however, wheth...

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Detalles Bibliográficos
Autores principales: Zeng, Guangwei, Lian, Chen, Yang, Pei, Zheng, Mingming, Ren, He, Wang, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594808/
https://www.ncbi.nlm.nih.gov/pubmed/31171760
http://dx.doi.org/10.18632/aging.101995