DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

Enhancer elements are a key regulatory feature of many important genes. Several general features including the presence of specific histone modifications are used to demarcate potentially active enhancers. Here we reveal that putative enhancers marked with H3 lysine 79 (H3K79) di or trimethylation (...

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Detalles Bibliográficos
Autores principales: Godfrey, Laura, Crump, Nicholas T., Thorne, Ross, Lau, I-Jun, Repapi, Emmanouela, Dimou, Dimitra, Smith, Alastair L., Harman, Joe R., Telenius, Jelena M., Oudelaar, A. Marieke, Downes, Damien J., Vyas, Paresh, Hughes, Jim R., Milne, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594956/
https://www.ncbi.nlm.nih.gov/pubmed/31243293
http://dx.doi.org/10.1038/s41467-019-10844-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594956/
https://www.ncbi.nlm.nih.gov/pubmed/31243293
http://dx.doi.org/10.1038/s41467-019-10844-3

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