TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis

Inflammaging induces osteoporosis by promoting bone destruction and inhibiting bone formation. TRAF3 limits bone destruction by inhibiting RANKL-induced NF-κB signaling in osteoclast precursors. However, the role of TRAF3 in mesenchymal progenitor cells (MPCs) is unknown. Mice with TRAF3 deleted in...

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Detalles Bibliográficos
Autores principales: Li, Jinbo, Ayoub, Akram, Xiu, Yan, Yin, Xiaoxiang, Sanders, James O., Mesfin, Addisu, Xing, Lianping, Yao, Zhenqiang, Boyce, Brendan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595054/
https://www.ncbi.nlm.nih.gov/pubmed/31243287
http://dx.doi.org/10.1038/s41467-019-10677-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595054/
https://www.ncbi.nlm.nih.gov/pubmed/31243287
http://dx.doi.org/10.1038/s41467-019-10677-0

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