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Direct Gα(q) Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation
Activation of Gα(q)-coupled receptors by inflammatory mediators inhibits cold-sensing TRPM8 channels, aggravating pain and inflammation. Both Gα(q) and the downstream hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP(2)) inhibit TRPM8. Here, I demonstrate that direct Gα(q) gating is essentia...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595177/ https://www.ncbi.nlm.nih.gov/pubmed/31216483 http://dx.doi.org/10.1016/j.celrep.2019.05.080 |