Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patients

BACKGROUND: Low-dose methotrexate (MTX) is the first-line therapy in early rheumatoid arthritis (eRA). Up to 40% of eRA patients do not benefit from MTX therapy. MTX has been shown to inhibit one-carbon metabolism, which is involved in the donation of methyl groups. In this study, we investigate bas...

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Detalles Bibliográficos
Autores principales: Gosselt, Helen R., van Zelst, Bertrand D., de Rotte, Maurits C. F. J., Hazes, Johanna M. W., de Jonge, Robert, Heil, Sandra G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595617/
https://www.ncbi.nlm.nih.gov/pubmed/31242943
http://dx.doi.org/10.1186/s13075-019-1936-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595617/
https://www.ncbi.nlm.nih.gov/pubmed/31242943
http://dx.doi.org/10.1186/s13075-019-1936-5

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