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Comparison of a time-varying covariate model and a joint model of time-to-event outcomes in the presence of measurement error and interval censoring: application to kidney transplantation

BACKGROUND: Tacrolimus (TAC) is an immunosuppressant drug given to kidney transplant recipients post-transplant to prevent antibody formation and kidney rejection. The optimal therapeutic dose for TAC is poorly defined and therapy requires frequent monitoring of drug trough levels. Analyzing the ass...

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Detalles Bibliográficos
Autores principales: Campbell, Kristen R., Juarez-Colunga, Elizabeth, Grunwald, Gary K., Cooper, James, Davis, Scott, Gralla, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595621/
https://www.ncbi.nlm.nih.gov/pubmed/31242848
http://dx.doi.org/10.1186/s12874-019-0773-1