NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal

BACKGROUND: Current efforts towards HIV-1 eradication focus on the reactivation and elimination of the latent viral reservoir, so-called shock and kill therapy. However, work from several groups indicates that infected cell death following virus reactivation is not guaranteed. Thus, it is imperative...

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Detalles Bibliográficos
Autores principales: Trinité, Benjamin, Zhang, Hongtao, Levy, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595680/
https://www.ncbi.nlm.nih.gov/pubmed/31242909
http://dx.doi.org/10.1186/s12977-019-0479-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595680/
https://www.ncbi.nlm.nih.gov/pubmed/31242909
http://dx.doi.org/10.1186/s12977-019-0479-9

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