Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential

A family of compounds typified by an anthranilic amide 1 was identified from a whole-cell screening effort targeted at identifying compounds that disrupt pH homeostasis in Mycobacterium tuberculosis. 1 demonstrated bactericidal activity against non-replicating M. tuberculosis in pH 4.5 buffer (MBC(4...

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Detalles Bibliográficos
Autores principales: Smith, Jake, Wescott, Heather, Early, Julie, Mullen, Steven, Guzman, Junitta, Odingo, Joshua, Lamar, Jason, Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596218/
https://www.ncbi.nlm.nih.gov/pubmed/31303991
http://dx.doi.org/10.1039/c9md00088g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596218/
https://www.ncbi.nlm.nih.gov/pubmed/31303991
http://dx.doi.org/10.1039/c9md00088g

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