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Aminopyrimidine–galactose hybrids are highly selective galectin-3 inhibitors

Galectins are a family of carbohydrate recognition proteins involved in, among other things, modulating cell signalling and cell–environment interactions, giving them roles in several pathologies like cancer and idiopathic lung fibrosis. Hence, developing new galectin inhibitors with high affinity a...

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Detalles Bibliográficos
Autores principales: Dahlqvist, Alexander, Zetterberg, Fredrik R., Leffler, Hakon, Nilsson, Ulf J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596385/
https://www.ncbi.nlm.nih.gov/pubmed/31303989
http://dx.doi.org/10.1039/c9md00183b