Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling

OBJECTIVE—: The Wnt/β-catenin pathway orchestrates development of the blood-brain barrier, but the downstream mechanisms involved at different developmental windows and in different central nervous system (CNS) tissues have remained elusive. APPROACH AND RESULTS—: Here, we create a new mouse model a...

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Detalles Bibliográficos
Autores principales: Jensen, Lasse D., Hot, Belma, Ramsköld, Daniel, Germano, Raoul F.V., Yokota, Chika, Giatrellis, Sarantis, Lauschke, Volker M., Hubmacher, Dirk, Li, Minerva X., Hupe, Mike, Arnold, Thomas D., Sandberg, Rickard, Frisén, Jonas, Trusohamn, Marta, Martowicz, Agnieszka, Wisniewska-Kruk, Joanna, Nyqvist, Daniel, Adams, Ralf H., Apte, Suneel S., Vanhollebeke, Benoit, Stenman, Jan M., Kele, Julianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597191/
https://www.ncbi.nlm.nih.gov/pubmed/31242033
http://dx.doi.org/10.1161/ATVBAHA.119.312388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597191/
https://www.ncbi.nlm.nih.gov/pubmed/31242033
http://dx.doi.org/10.1161/ATVBAHA.119.312388

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