A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

Volume-regulated anion channels (VRACs) are central to cell volume regulation. Recently identified as hetero-hexamers formed by LRRC8 proteins, their activation mechanism remains elusive. Here, we measured Förster resonance energy transfer (FRET) between fluorescent proteins fused to the C-termini o...

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Detalles Bibliográficos
Autores principales: König, Benjamin, Hao, Yuchen, Schwartz, Sophia, Plested, Andrew JR, Stauber, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597245/
https://www.ncbi.nlm.nih.gov/pubmed/31210638
http://dx.doi.org/10.7554/eLife.45421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597245/
https://www.ncbi.nlm.nih.gov/pubmed/31210638
http://dx.doi.org/10.7554/eLife.45421

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