Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Rab proteins play an essential role in regulating intracellular membrane trafficking processes. Rab activity is dependent upon geranylgeranylation, a post-translational modification that involves the addition of 20-carbon isoprenoid chains via the enzyme geranylgeranyl transferase (GGTase) II. We ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Haney, Staci L., Varney, Michelle L., Chhonker, Yashpal S., Shin, Simon, Mehla, Kamiya, Crawford, Ayrianne J., Smith, Heather Jensen, Smith, Lynette M., Murry, Daryl J., Hollingsworth, Michael A., Holstein, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597278/
https://www.ncbi.nlm.nih.gov/pubmed/30918331
http://dx.doi.org/10.1038/s41388-019-0794-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597278/
https://www.ncbi.nlm.nih.gov/pubmed/30918331
http://dx.doi.org/10.1038/s41388-019-0794-6

Ejemplares similares