Cargando…

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Rab proteins play an essential role in regulating intracellular membrane trafficking processes. Rab activity is dependent upon geranylgeranylation, a post-translational modification that involves the addition of 20-carbon isoprenoid chains via the enzyme geranylgeranyl transferase (GGTase) II. We ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haney, Staci L., Varney, Michelle L., Chhonker, Yashpal S., Shin, Simon, Mehla, Kamiya, Crawford, Ayrianne J., Smith, Heather Jensen, Smith, Lynette M., Murry, Daryl J., Hollingsworth, Michael A., Holstein, Sarah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597278/ https://www.ncbi.nlm.nih.gov/pubmed/30918331 http://dx.doi.org/10.1038/s41388-019-0794-6

Ejemplares similares

Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma
por: Haney, Staci L., et al.
Publicado: (2022)

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors
por: Haney, Staci L., et al.
Publicado: (2017)

Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target
por: Muehlebach, Molly E., et al.
Publicado: (2023)

Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC-MS/MS
por: Chhonker, Yashpal S., et al.
Publicado: (2018)

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
por: Gabriel, Heloisa B, et al.
Publicado: (2018)

Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum
por: Jordão, Fabiana M, et al.
Publicado: (2013)

Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
por: Agabiti, Sherry S., et al.
Publicado: (2019)

Functional analysis and subcellular localization of two geranylgeranyl diphosphate synthases from Penicillium paxilli
por: Saikia, Sanjay, et al.
Publicado: (2009)

Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma
por: Wang, Xiaoxia, et al.
Publicado: (2018)

Characterization of the Geranylgeranyl Diphosphate Synthase Gene in Acyrthosiphon pisum (Hemiptera: Aphididae) and Its Association With Carotenoid Biosynthesis
por: Ding, Bi-Yue, et al.
Publicado: (2019)

Correction to: A Single Arabidopsis Gene Encodes Two Differentially Targeted Geranylgeranyl Diphosphate Synthase Isoforms
por: Ruiz-Sola, M Águila, et al.
Publicado: (2022)

A Small Subunit of Geranylgeranyl Diphosphate Synthase Functions as an Active Regulator of Carotenoid Synthesis in Nicotiana tabacum
por: Dong, Chen, et al.
Publicado: (2023)

A quantitative method to measure geranylgeranyl diphosphate (GGPP) and geranylgeranyl monophosphate (GGP) in tomato (Solanum lycopersicum) fruit
por: Zita, Wayne, et al.
Publicado: (2023)

Synthesis of isoprenoid bisphosphonate ethers through C–P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase
por: Zhou, Xiang, et al.
Publicado: (2014)

Biosynthesis of Taxadiene in Saccharomyces cerevisiae : Selection of Geranylgeranyl Diphosphate Synthase Directed by a Computer-Aided Docking Strategy
por: Ding, Ming-zhu, et al.
Publicado: (2014)

Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation
por: Agabiti, Sherry S, et al.
Publicado: (2017)

Functional verification and characterization of a type-III geranylgeranyl diphosphate synthase gene from Sporobolomyces pararoseus NGR
por: Yan, Jianyu, et al.
Publicado: (2022)

Genetic Polymorphism of Geranylgeranyl Diphosphate Synthase (GGSP1) Predicts Bone Density Response to Bisphosphonate Therapy in Korean Women
por: Choi, Hyung Jin, et al.
Publicado: (2010)

LC–MS/MS method for simultaneous determination of diethylcarbamazine, albendazole and albendazole metabolites in human plasma: Application to a clinical pharmacokinetic study
por: Chhonker, Yashpal S., et al.
Publicado: (2018)

Genome-wide characterization and expression analysis of geranylgeranyl diphosphate synthase genes in cotton (Gossypium spp.) in plant development and abiotic stresses
por: Ali, Faiza, et al.
Publicado: (2020)

Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity
por: Li, Heng, et al.
Publicado: (2022)

Simultaneous Quantitation of S(+)- and R(−)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC–APCI–MS/MS: An Application for Clinical Studies
por: He, Qingfeng, et al.
Publicado: (2020)

A Concise Review of Liquid Chromatography-Mass Spectrometry-Based Quantification Methods for Short Chain Fatty Acids as Endogenous Biomarkers
por: Trivedi, Neerja, et al.
Publicado: (2022)

A Simultaneous Extraction/Derivatization Strategy for Quantitation of Vitamin D in Dried Blood Spots Using LC–MS/MS: Application to Biomarker Study in Subjects Tested for SARS-CoV-2
por: Chhonker, Yashpal S., et al.
Publicado: (2023)

Simultaneous Quantitation of Lipid Biomarkers for Inflammatory Bowel Disease Using LC–MS/MS
por: Chhonker, Yashpal S., et al.
Publicado: (2021)

Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1
por: Elsabrouty, Rania, et al.
Publicado: (2021)

A Selective and Sensitive LC-MS/MS Method for Quantitation of Indole in Mouse Serum and Tissues
por: Joshi, Vineet, et al.
Publicado: (2022)

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase
por: Baron, Rudi A., et al.
Publicado: (2009)

Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis
por: Feng, Yuchi, et al.
Publicado: (2020)

Evolution of isoprenyl diphosphate synthase-like terpene synthases in fungi
por: Wei, Guo, et al.
Publicado: (2020)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia
por: Samuelson, Derrick R., et al.
Publicado: (2022)

Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads
por: Sinko, William, et al.
Publicado: (2014)

Eating Pattern and Nutritional Risks among People with Multiple Sclerosis Following a Modified Paleolithic Diet
por: Titcomb, Tyler J., et al.
Publicado: (2020)

Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq
por: Engprasert, Surang, et al.
Publicado: (2004)

Relationship between β-Carotene Accumulation and Geranylgeranyl Pyrophosphate Synthase in Different Species of Dunaliella
por: Xu, Lu, et al.
Publicado: (2021)

The essential roles of cytidine diphosphate‐diacylglycerol synthase in bloodstream form Trypanosoma brucei
por: Lilley, Alison C., et al.
Publicado: (2014)

Targeting the Isoprenoid Biosynthetic Pathway in Multiple Myeloma
por: Haney, Staci L., et al.
Publicado: (2022)

Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening
por: Lindert, Steffen, et al.
Publicado: (2013)

Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness
por: Kim, Hee Yeon, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lv9bqusdjsv0osku8t3pmq5hfq