Upregulated Claudin-1 Expression Promotes Colitis-associated Cancer by promoting β-Catenin phosphorylation and activation in Notch/p-AKT Dependent Manner

In IBD patients, integration between a hyper-activated immune system and epithelial cell plasticity underlies colon cancer development. However, molecular regulation of such a circuity remains undefined. Claudin-1(Cld-1), a tight-junction integral protein deregulation alters colonic epithelial cell...

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Detalles Bibliográficos
Autores principales: Gowrikumar, Saiprasad, Ahmad, Rizwan, Uppada, Srijayaprakash Babu, Washington, Mary K, Shi, Chanjuan, Singh, Amar B., Dhawan, Punita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597297/
https://www.ncbi.nlm.nih.gov/pubmed/30971761
http://dx.doi.org/10.1038/s41388-019-0795-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597297/
https://www.ncbi.nlm.nih.gov/pubmed/30971761
http://dx.doi.org/10.1038/s41388-019-0795-5

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