FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Farnesyl Diphosphate Synthase (FDPS), a mevalonate pathway enzyme, is highly expressed in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional and clinical significance of FDPS in cancer remains unexplored. We evaluated the FDPS expression and its cancer-associated...

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Detalles Bibliográficos
Autores principales: Seshacharyulu, Parthasarathy, Rachagani, Satyanarayana, Muniyan, Sakthivel, Siddiqui, Jawed A., Cruz, Eric, Sharma, Sunandini, Krishnan, Ramakrishnan, Killips, Brigham J., Sheinin, Yuri, Lele, Subodh M., Smith, Lynette M., Talmon, Geoffrey A., Ponnusamy, Moorthy P., Datta, Kaustubh, Batra, Surinder K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597298/
https://www.ncbi.nlm.nih.gov/pubmed/30914801
http://dx.doi.org/10.1038/s41388-019-0791-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597298/
https://www.ncbi.nlm.nih.gov/pubmed/30914801
http://dx.doi.org/10.1038/s41388-019-0791-9

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