Cargando…

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Farnesyl Diphosphate Synthase (FDPS), a mevalonate pathway enzyme, is highly expressed in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional and clinical significance of FDPS in cancer remains unexplored. We evaluated the FDPS expression and its cancer-associated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seshacharyulu, Parthasarathy, Rachagani, Satyanarayana, Muniyan, Sakthivel, Siddiqui, Jawed A., Cruz, Eric, Sharma, Sunandini, Krishnan, Ramakrishnan, Killips, Brigham J., Sheinin, Yuri, Lele, Subodh M., Smith, Lynette M., Talmon, Geoffrey A., Ponnusamy, Moorthy P., Datta, Kaustubh, Batra, Surinder K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597298/ https://www.ncbi.nlm.nih.gov/pubmed/30914801 http://dx.doi.org/10.1038/s41388-019-0791-9

Ejemplares similares

MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism
por: Muniyan, Sakthivel, et al.
Publicado: (2016)

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer
por: Mimeault, Murielle, et al.
Publicado: (2015)

Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling
por: Seshacharyulu, Parthasarathy, et al.
Publicado: (2021)

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma
por: Vaz, Arokia Priyanka, et al.
Publicado: (2015)

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer
por: Seshacharyulu, Parthasarathy, et al.
Publicado: (2014)

Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model
por: Mallya, Kavita, et al.
Publicado: (2020)

GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation
por: Siddiqui, Jawed Akhtar, et al.
Publicado: (2022)

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
por: Lakshmanan, Imayavaramban, et al.
Publicado: (2015)

Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma
por: Vengoji, Raghupathy, et al.
Publicado: (2021)

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells
por: Karmakar, Saswati, et al.
Publicado: (2017)

MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells
por: Ponnusamy, Moorthy P, et al.
Publicado: (2011)

Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer
por: Leon, Frank, et al.
Publicado: (2021)

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia
por: Dey, Parama, et al.
Publicado: (2014)

Selective inhibition of stemness through EGFR/FOXA2/SOX9 axis reduces pancreatic cancer metastasis
por: Kaushik, Garima, et al.
Publicado: (2020)

ST6GalNAc‐I promotes lung cancer metastasis by altering MUC5AC sialylation
por: Lakshmanan, Imayavaramban, et al.
Publicado: (2021)

MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer
por: Pai, Priya, et al.
Publicado: (2016)

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy
por: Rachagani, Satyanarayana, et al.
Publicado: (2012)

Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells
por: Barkeer, Srikanth, et al.
Publicado: (2018)

Editorial: Metastatic Castration Resistant Prostate Cancer: Prognosis and Treatment
por: Muniyan, Sakthivel, et al.
Publicado: (2022)

Comparative Study of Subcutaneous and Orthotopic Mouse Models of Prostate Cancer: Vascular Perfusion, Vasculature Density, Hypoxic Burden and BB2r-Targeting Efficacy
por: Zhang, Wenting, et al.
Publicado: (2019)

Nicotine/Cigarette-smoke Promotes Metastasis of Pancreatic Cancer Through α7nAChR-mediated MUC4 Up-regulation
por: Momi, Navneet, et al.
Publicado: (2012)

Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation
por: Chugh, Seema, et al.
Publicado: (2016)

Pathobiological Implications of MUC16 Expression in Pancreatic Cancer
por: Haridas, Dhanya, et al.
Publicado: (2011)

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells
por: Vengoji, Raghupathy, et al.
Publicado: (2019)

Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer
por: Poelaert, Brittany J., et al.
Publicado: (2021)

MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells
por: Mukhopadhyay, Partha, et al.
Publicado: (2013)

MUC16 promotes triple-negative breast cancer lung metastasis by modulating RNA-binding protein ELAVL1/HUR
por: Chaudhary, Sanjib, et al.
Publicado: (2023)

Ovarian cancer: emerging concept on cancer stem cells
por: Ponnusamy, Moorthy P, et al.
Publicado: (2008)

Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer
por: Jahan, Rahat, et al.
Publicado: (2019)

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma
por: Abate, Mario, et al.
Publicado: (2017)

Gut microbiota: a non-target victim of pesticide-induced toxicity
por: Sharma, Tusha, et al.
Publicado: (2023)

Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway
por: Pandey, P, et al.
Publicado: (2013)

Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered Kras(G12D);Pdx1-Cre mouse (KC) model
por: Rachagani, Satyanarayana, et al.
Publicado: (2015)

Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma
por: Kanteti, Rajani, et al.
Publicado: (2018)

Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis
por: Pandey, Poomy, et al.
Publicado: (2014)

RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment
por: Hein, Ashley L., et al.
Publicado: (2016)

Human RNA Polymerase II-Association Factor 1 (hPaf1/PD2) Regulates Histone Methylation and Chromatin Remodeling in Pancreatic Cancer
por: Dey, Parama, et al.
Publicado: (2011)

Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis
por: Barkeer, Srikanth, et al.
Publicado: (2018)

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells
por: Das, Srustidhar, et al.
Publicado: (2015)

The role of fibrinogen, fibrin and fibrin(ogen) degradation products (FDPs) in tumor progression
por: Kołodziejczyk, Joanna, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_c8ni5km01u47kjc467008p446j