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Interplay of Darwinian Selection, Lamarckian Induction and Microvesicle Transfer on Drug Resistance in Cancer

Development of drug resistance in cancer has major implications for patients’ outcome. It is related to processes involved in the decrease of drug efficacy, which are strongly influenced by intratumor heterogeneity and changes in the microenvironment. Heterogeneity arises, to a large extent, from ge...

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Detalles Bibliográficos
Autores principales: Álvarez-Arenas, Arturo, Podolski-Renic, Ana, Belmonte-Beitia, Juan, Pesic, Milica, Calvo, Gabriel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597577/
https://www.ncbi.nlm.nih.gov/pubmed/31249353
http://dx.doi.org/10.1038/s41598-019-45863-z