A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children

Recently a framework was presented to assess whether pediatric covariate models for clearance can be extrapolated between drugs sharing elimination pathways, based on extraction ratio, protein binding, and other drug properties. Here we evaluate when a pediatric covariate function for midazolam clea...

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Detalles Bibliográficos
Autores principales: Brussee, Janneke M., Krekels, Elke H. J., Calvier, Elisa A. M., Palić, Semra, Rostami-Hodjegan, Amin, Danhof, Meindert, Barrett, Jeffrey S., de Wildt, Saskia N., Knibbe, Catherijne A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597607/
https://www.ncbi.nlm.nih.gov/pubmed/31250333
http://dx.doi.org/10.1208/s12248-019-0351-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597607/
https://www.ncbi.nlm.nih.gov/pubmed/31250333
http://dx.doi.org/10.1208/s12248-019-0351-9

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