Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model

We characterized phenotypes in RBL-2H3 mast cells transfected with human alpha synuclein (a-syn) using stimulated exocytosis of recycling endosomes as a proxy for similar activities of synaptic vesicles in neurons. We found that low expression of a-syn inhibits stimulated exocytosis and that higher...

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Detalles Bibliográficos
Autores principales: Ramezani, Meraj, Wilkes, Marcus M., Das, Tapojyoti, Holowka, David, Eliezer, David, Baird, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597712/
https://www.ncbi.nlm.nih.gov/pubmed/31263746
http://dx.doi.org/10.1038/s41531-019-0084-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597712/
https://www.ncbi.nlm.nih.gov/pubmed/31263746
http://dx.doi.org/10.1038/s41531-019-0084-6

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