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Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model
We characterized phenotypes in RBL-2H3 mast cells transfected with human alpha synuclein (a-syn) using stimulated exocytosis of recycling endosomes as a proxy for similar activities of synaptic vesicles in neurons. We found that low expression of a-syn inhibits stimulated exocytosis and that higher...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597712/ https://www.ncbi.nlm.nih.gov/pubmed/31263746 http://dx.doi.org/10.1038/s41531-019-0084-6 |