C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease

A pathological feature of Parkinson's disease (PD) is Lewy bodies (LBs) composed of α-synuclein (α-syn) amyloid fibrils. α-Syn is a 140 amino acids–long protein, but truncated α-syn is enriched in LBs. The proteolytic processes that generate these truncations are not well-understood. On the bas...

Descripción completa

Detalles Bibliográficos
Autores principales: McGlinchey, Ryan P., Lacy, Shannon M., Huffer, Katherine E., Tayebi, Nahid, Sidransky, Ellen, Lee, Jennifer C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597809/
https://www.ncbi.nlm.nih.gov/pubmed/31092553
http://dx.doi.org/10.1074/jbc.RA119.008930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597809/
https://www.ncbi.nlm.nih.gov/pubmed/31092553
http://dx.doi.org/10.1074/jbc.RA119.008930

Ejemplares similares