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Ryanodine Receptor 2 Contributes to Impaired Protein Localization in Cyclic Nucleotide-Gated Channel Deficiency

The photoreceptor cyclic nucleotide-gated (CNG) channel plays a pivotal role in phototransduction and cellular calcium homeostasis. Mutations in the cone photoreceptor CNG channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophies. CNG channel deficiency leads to endopla...

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Detalles Bibliográficos
Autores principales: Ma, Hongwei, Yang, Fan, Butler, Michael R., Rapp, Jacob, Le, Yun-Zheng, Ding, Xi-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597858/
https://www.ncbi.nlm.nih.gov/pubmed/31182474
http://dx.doi.org/10.1523/ENEURO.0119-19.2019