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Substitution of Human Papillomavirus Type 16 L2 Neutralizing Epitopes Into L1 Surface Loops: The Effect on Virus-Like Particle Assembly and Immunogenicity

Cervical cancer caused by infection with human papillomaviruses (HPVs) is the fourth most common cancer in women globally, with the burden mainly in developing countries due to limited healthcare resources. Current vaccines based on virus-like particles (VLPs) assembled from recombinant expression o...

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Detalles Bibliográficos
Autores principales: Chabeda, Aleyo, van Zyl, Albertha R., Rybicki, Edward P., Hitzeroth, Inga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597877/
https://www.ncbi.nlm.nih.gov/pubmed/31281327
http://dx.doi.org/10.3389/fpls.2019.00779