Cargando…

Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer’s Disease via Peroxisome Proliferator-Activated Receptor α

Deposition of extracellular senile plaques containing amyloid-β is one of the major neuropathological characteristics of Alzheimer’s disease (AD). Therefore, targeting amyloid-β dyshomeostasis is an important therapeutic strategy for treatment of AD. In this study, we demonstrate that gemfibrozil, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chandra, Sujyoti, Pahan, Kalipada
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2019
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597963/ https://www.ncbi.nlm.nih.gov/pubmed/31259309 http://dx.doi.org/10.3233/ADR-190104

Ejemplares similares

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer’s disease mouse model
por: Chandra, Sujyoti, et al.
Publicado: (2018)

Safety and potential efficacy of gemfibrozil as a supportive treatment for children with late infantile neuronal ceroid lipofuscinosis and other lipid storage disorders
por: Kim, Kyeongsoon, et al.
Publicado: (2017)

Treadmill exercise reduces α-synuclein spreading via PPARα
por: Dutta, Debashis, et al.
Publicado: (2022)

The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections
por: Kim, Yi Sak, et al.
Publicado: (2020)

Upregulation of IL-1 Receptor Antagonist by Aspirin in Glial Cells via Peroxisome Proliferator-Activated Receptor-Alpha
por: Chakrabarti, Sudipta, et al.
Publicado: (2021)

Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer’s pathology
por: Rangasamy, Suresh B., et al.
Publicado: (2018)

A Physically-Modified Saline Suppresses Neuronal Apoptosis, Attenuates Tau Phosphorylation and Protects Memory in an Animal Model of Alzheimer's Disease
por: Modi, Khushbu K., et al.
Publicado: (2014)

Correction: A Physically-Modified Saline Suppresses Neuronal Apoptosis, Attenuates Tau Phosphorylation and Protects Memory in an Animal Model of Alzheimer's Disease
por: Modi, Khushbu K., et al.
Publicado: (2017)

Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21(rac) and Protect Memory and Learning in an Animal Model of Alzheimer’s Disease
por: Modi, Khushbu K., et al.
Publicado: (2015)

Bullous dermatosis of childhood induced by gemfibrozil
por: Abtahi-Naeini, Bahareh, et al.
Publicado: (2015)

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology
por: Das, Pritam, et al.
Publicado: (2012)

Zileuton Improves Memory Deficits, Amyloid and Tau Pathology in a Mouse Model of Alzheimer’s Disease with Plaques and Tangles
por: Chu, Jin, et al.
Publicado: (2013)

Can cinnamon bring aroma in Parkinson's disease treatment?
por: Pahan, Priyanka, et al.
Publicado: (2015)

Smooth or Risky Revisit of an Old Malaria Drug for COVID-19?
por: Pahan, Priyanka, et al.
Publicado: (2020)

Alzheimer’s Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α
por: Sáez-Orellana, Francisco, et al.
Publicado: (2020)

Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology
por: Rahman, M. Mahafuzur, et al.
Publicado: (2021)

Prospects of Cinnamon in Multiple Sclerosis
por: Pahan, Kalipada
Publicado: (2015)

Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism
por: Cunningham, Michael L., et al.
Publicado: (2010)

Gemfibrozil reduces lipid accumulation in SMMC-7721 cells via the involvement of PPARα and SREBP1
por: Zhang, Xiaonan, et al.
Publicado: (2019)

The impact of lipid-lowering medications on coronary artery plaque characteristics
por: Pulipati, Vishnu Priya, et al.
Publicado: (2021)

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
por: Hashimoto, Tadafumi, et al.
Publicado: (2020)

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease
por: Neitzel, Julia, et al.
Publicado: (2021)

Does the lipid-lowering peroxisome proliferator-activated receptors ligand bezafibrate prevent colon cancer in patients with coronary artery disease?
por: Tenenbaum, Alexander, et al.
Publicado: (2008)

Amyloid-Lowering Monoclonal Antibodies for the Treatment of Early Alzheimer’s Disease
por: Leisher, Solana, et al.
Publicado: (2023)

Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering
por: Härdtner, Carmen, et al.
Publicado: (2020)

Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
por: Lam, Suzanne, et al.
Publicado: (2022)

Myelin Basic Protein-primed T Helper 2 Cells Suppress Microglial Activation via AlphaVBeta3 Integrin: Implications for Multiple Sclerosis
por: Roy, Avik, et al.
Publicado: (2013)

Cinnamon Ameliorates Experimental Allergic Encephalomyelitis in Mice via Regulatory T Cells: Implications for Multiple Sclerosis Therapy
por: Mondal, Susanta, et al.
Publicado: (2015)

Is COVID-19 Gender-sensitive?
por: Mukherjee, Shreya, et al.
Publicado: (2021)

Cinnamein Inhibits the Induction of Nitric Oxide and Proinflammatory Cytokines in Macrophages, Microglia and Astrocytes
por: Pahan, Swarupa, et al.
Publicado: (2023)

Lipid + Alzheimer's plaque = problem
por: Robinson, Richard
Publicado: (2007)

Gemfibrozil as a potential heme-independent sGC activator
por: Sobolevsky, Michael, et al.
Publicado: (2011)

Enhanced antihyperlipidemic potential of gemfibrozil under co-administration with piperine
por: Mohanalakshmi, S., et al.
Publicado: (2021)

Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls
por: Esparza, Thomas J., et al.
Publicado: (2018)

Doxorubicin-Induced Cardiac Toxicity Is Mediated by Lowering of Peroxisome Proliferator-Activated Receptor δ Expression in Rats
por: Chen, Zhih-Cherng, et al.
Publicado: (2013)

A verrucous plaque on the lower leg
por: Drusinsky, Sarina, et al.
Publicado: (2013)

Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer’s Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques
por: Su, Dan, et al.
Publicado: (2021)

Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease
por: Thomas, Riya, et al.
Publicado: (2020)

Nanoscale structure of amyloid-β plaques in Alzheimer’s disease
por: Querol-Vilaseca, Marta, et al.
Publicado: (2019)

Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease
por: Luo, Ziyi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tfa0b0cs5ptg7ql79btvhea8nb