Cargando…
7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
[Image: see text] Mitragyna speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction. Recently, growing use of the plant in the United States and concerns that kratom r...
Autores principales: | Kruegel, Andrew C., Uprety, Rajendra, Grinnell, Steven G., Langreck, Cory, Pekarskaya, Elizabeth A., Le Rouzic, Valerie, Ansonoff, Michael, Gassaway, Madalee M., Pintar, John E., Pasternak, Gavril W., Javitch, Jonathan A., Majumdar, Susruta, Sames, Dalibor |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598159/ https://www.ncbi.nlm.nih.gov/pubmed/31263758 http://dx.doi.org/10.1021/acscentsci.9b00141 |
Ejemplares similares
-
In silico investigation of mitragynine and 7-hydroxymitragynine metabolism
por: Limpanuparb, Taweetham, et al.
Publicado: (2019) -
The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine
por: Hill, Rob, et al.
Publicado: (2022) -
Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
por: Bhowmik, Srijita, et al.
Publicado: (2021) -
Unveiling 7-Hydroxymitragynine as the Key Active Metabolite of Mitragynine and the Promise for Creating Novel Pain Relievers
por: Spetea, Mariana, et al.
Publicado: (2019) -
The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist
por: Gassaway, M M, et al.
Publicado: (2014)