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Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion
This study was conducted to formulate, characterize, and investigate the bioavailability of hydrocortisone (HCT) when prepared as solid dispersions. HCT was mixed in an organic solvent with polyethylene glycol 4000 (PEG 4000) and Kolliphor® P 407. Spray drying technique was employed to form a solid...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598222/ https://www.ncbi.nlm.nih.gov/pubmed/31297016 http://dx.doi.org/10.1016/j.jsps.2019.03.004 |
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author | Altamimi, Mohammad A. Elzayat, Ehab M. Qamar, Wajhul Alshehri, Sultan M. Sherif, Abdelrahman Y. Haq, Nazrul Shakeel, Faiyaz |
author_facet | Altamimi, Mohammad A. Elzayat, Ehab M. Qamar, Wajhul Alshehri, Sultan M. Sherif, Abdelrahman Y. Haq, Nazrul Shakeel, Faiyaz |
author_sort | Altamimi, Mohammad A. |
collection | PubMed |
description | This study was conducted to formulate, characterize, and investigate the bioavailability of hydrocortisone (HCT) when prepared as solid dispersions. HCT was mixed in an organic solvent with polyethylene glycol 4000 (PEG 4000) and Kolliphor® P 407. Spray drying technique was employed to form a solid dispersion formulation at a specific ratio. Physical and chemical characterization of the formed particles were achieved using differential scanning calorimetry, scanning electron microscopy, Fourier transform infrared spectroscopy, and powder X-ray diffractometry. Furthermore, comparative in vitro and in vivo studies were conducted between the formulated particles against neat HCT. The formulated solid dispersion showed elongated particles with leaf-like structure. Formation of new chemical bonds in the formed particle was suggested due to the change in the vibrational wave numbers and the significant improvement in the bioavailability of the dispersed particles proved the importance of this technique. |
format | Online Article Text |
id | pubmed-6598222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-65982222019-07-11 Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion Altamimi, Mohammad A. Elzayat, Ehab M. Qamar, Wajhul Alshehri, Sultan M. Sherif, Abdelrahman Y. Haq, Nazrul Shakeel, Faiyaz Saudi Pharm J Original Article This study was conducted to formulate, characterize, and investigate the bioavailability of hydrocortisone (HCT) when prepared as solid dispersions. HCT was mixed in an organic solvent with polyethylene glycol 4000 (PEG 4000) and Kolliphor® P 407. Spray drying technique was employed to form a solid dispersion formulation at a specific ratio. Physical and chemical characterization of the formed particles were achieved using differential scanning calorimetry, scanning electron microscopy, Fourier transform infrared spectroscopy, and powder X-ray diffractometry. Furthermore, comparative in vitro and in vivo studies were conducted between the formulated particles against neat HCT. The formulated solid dispersion showed elongated particles with leaf-like structure. Formation of new chemical bonds in the formed particle was suggested due to the change in the vibrational wave numbers and the significant improvement in the bioavailability of the dispersed particles proved the importance of this technique. Elsevier 2019-07 2019-03-07 /pmc/articles/PMC6598222/ /pubmed/31297016 http://dx.doi.org/10.1016/j.jsps.2019.03.004 Text en © 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Altamimi, Mohammad A. Elzayat, Ehab M. Qamar, Wajhul Alshehri, Sultan M. Sherif, Abdelrahman Y. Haq, Nazrul Shakeel, Faiyaz Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion |
title | Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion |
title_full | Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion |
title_fullStr | Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion |
title_full_unstemmed | Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion |
title_short | Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion |
title_sort | evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598222/ https://www.ncbi.nlm.nih.gov/pubmed/31297016 http://dx.doi.org/10.1016/j.jsps.2019.03.004 |
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