VARSCOT: variant-aware detection and scoring enables sensitive and personalized off-target detection for CRISPR-Cas9

BACKGROUND: Natural variations in a genome can drastically alter the CRISPR-Cas9 off-target landscape by creating or removing sites. Despite the resulting potential side-effects from such unaccounted for sites, current off-target detection pipelines are not equipped to include variant information. T...

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Detalles Bibliográficos
Autores principales: Wilson, Laurence O. W., Hetzel, Sara, Pockrandt, Christopher, Reinert, Knut, Bauer, Denis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598273/
https://www.ncbi.nlm.nih.gov/pubmed/31248401
http://dx.doi.org/10.1186/s12896-019-0535-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598273/
https://www.ncbi.nlm.nih.gov/pubmed/31248401
http://dx.doi.org/10.1186/s12896-019-0535-5

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