Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo

BACKGROUND: Metastasis is a leading cause of breast cancer mortality. The induction of epithelial-to-mesenchymal transition (EMT) and complex oncogenic signaling is a vital step in the evolution of highly metastatic and therapeutically-intractable breast cancer; necessitating novel target discovery...

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Detalles Bibliográficos
Autores principales: Chen, Jia-Hong, Huang, Wen-Chien, Bamodu, Oluwaseun Adebayo, Chang, Peter Mu-Hsin, Chao, Tsu-Yi, Huang, Tse-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598338/
https://www.ncbi.nlm.nih.gov/pubmed/31248373
http://dx.doi.org/10.1186/s12885-019-5811-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598338/
https://www.ncbi.nlm.nih.gov/pubmed/31248373
http://dx.doi.org/10.1186/s12885-019-5811-1

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