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Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein

The Prp8 intein is one of the most widespread eukaryotic inteins, present in important pathogenic fungi, including Cryptococcus and Aspergillus species. Because the processed Prp8 carries out essential and non-redundant cellular functions, a Prp8 intein inhibitor is a mechanistically novel antifunga...

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Detalles Bibliográficos
Autores principales: Li, Zhong, Fu, Bin, Green, Cathleen M., Liu, Binbin, Zhang, Jing, Lang, Yuekun, Chaturvedi, Sudha, Belfort, Marlene, Liao, Guojian, Li, Hongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598491/
https://www.ncbi.nlm.nih.gov/pubmed/31223062
http://dx.doi.org/10.1080/22221751.2019.1625727