A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice

Dengue virus (DENV) induces strong T and B cell responses upon infection. Hence, it is difficult to determine the contribution of cell-mediated immunity alone in the long lasting protection against DENV infection and disease. Numerous CD4+ and CD8+ T cell epitopes have been identified, mainly in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Roth, Claude, Cantaert, Tineke, Colas, Chloé, Prot, Matthieu, Casadémont, Isabelle, Levillayer, Laurine, Thalmensi, Jessie, Langlade-Demoyen, Pierre, Gerke, Christiane, Bahl, Kapil, Ciaramella, Giuseppe, Simon-Loriere, Etienne, Sakuntabhai, Anavaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598640/
https://www.ncbi.nlm.nih.gov/pubmed/31293584
http://dx.doi.org/10.3389/fimmu.2019.01424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598640/
https://www.ncbi.nlm.nih.gov/pubmed/31293584
http://dx.doi.org/10.3389/fimmu.2019.01424

Ejemplares similares