In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents

BACKGROUND: Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and efficacy profile are far from ideal. Farmanguinhos from Fiocruz has developed seven nitroimidazole compounds (4-10) analogs of megazol (3). OBJECTIVES: To evalu...

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Detalles Bibliográficos
Autores principales: Von Trompowsky, Ana Claudia Manoel, Conde, Taline Ramos, Lemos, Renata Calil, Quaresma, Bruna Maria CS, Pitombeira, Marcelly Cristina SR, de Carvalho, Alcione Silva, Boechat, Núbia, Salomão, Kelly, de Castro, Solange Lisboa, Zamith, Helena Pereira da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598759/
https://www.ncbi.nlm.nih.gov/pubmed/31271593
http://dx.doi.org/10.1590/0074-02760190017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598759/
https://www.ncbi.nlm.nih.gov/pubmed/31271593
http://dx.doi.org/10.1590/0074-02760190017

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