17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAF(V600E) inhibitors in melanoma cells of different genetic subtypes

Outcomes of melanoma patient treatment remain unsatisfactory despite accessibility of oncoprotein-targeting drugs and immunotherapy. Here, we reported that 17-aminogeldanamycin more potently activated caspase-3/7 in BRAF(V600E) melanoma cells than geldanamycin, another inhibitor of heat shock protei...

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Detalles Bibliográficos
Autores principales: Mielczarek-Lewandowska, Aleksandra, Sztiller-Sikorska, Malgorzata, Osrodek, Marta, Czyz, Malgorzata, Hartman, Mariusz L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598962/
https://www.ncbi.nlm.nih.gov/pubmed/30989459
http://dx.doi.org/10.1007/s10495-019-01542-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598962/
https://www.ncbi.nlm.nih.gov/pubmed/30989459
http://dx.doi.org/10.1007/s10495-019-01542-y

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