PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling

Centromeres provide a pivotal function for faithful chromosome segregation. They serve as a foundation for the assembly of the kinetochore complex and spindle connection, which is essential for chromosome biorientation. Cells lacking Polo-like kinase 1 (PLK1) activity suffer severe chromosome alignm...

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Detalles Bibliográficos
Autores principales: Addis Jones, Owen, Tiwari, Ankana, Olukoga, Tomisin, Herbert, Alex, Chan, Kok-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599003/
https://www.ncbi.nlm.nih.gov/pubmed/31253795
http://dx.doi.org/10.1038/s41467-019-10938-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599003/
https://www.ncbi.nlm.nih.gov/pubmed/31253795
http://dx.doi.org/10.1038/s41467-019-10938-y

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