Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening

Drug development often relies on high-throughput cell-based screening of large compound libraries. However, the lack of miniaturized and parallelized methodologies in chemistry as well as strict separation and incompatibility of the synthesis of bioactive compounds from their biological screenings m...

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Detalles Bibliográficos
Autores principales: Benz, Maximilian, Molla, Mijanur R., Böser, Alexander, Rosenfeld, Alisa, Levkin, Pavel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599004/
https://www.ncbi.nlm.nih.gov/pubmed/31253767
http://dx.doi.org/10.1038/s41467-019-10685-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599004/
https://www.ncbi.nlm.nih.gov/pubmed/31253767
http://dx.doi.org/10.1038/s41467-019-10685-0

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