Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53

Intrinsically disordered regions (IDRs) of proteins are involved in many diseases. The rational drug design against disease-mediating proteins is often based on the 3D structure; however, the flexible structure of IDRs hinders the use of such structure-based design methods. Here, we developed a rati...

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Detalles Bibliográficos
Autores principales: Kamagata, Kiyoto, Mano, Eriko, Itoh, Yuji, Wakamoto, Takuro, Kitahara, Ryo, Kanbayashi, Saori, Takahashi, Hiroto, Murata, Agato, Kameda, Tomoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599006/
https://www.ncbi.nlm.nih.gov/pubmed/31253862
http://dx.doi.org/10.1038/s41598-019-44688-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599006/
https://www.ncbi.nlm.nih.gov/pubmed/31253862
http://dx.doi.org/10.1038/s41598-019-44688-0

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