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Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53
Intrinsically disordered regions (IDRs) of proteins are involved in many diseases. The rational drug design against disease-mediating proteins is often based on the 3D structure; however, the flexible structure of IDRs hinders the use of such structure-based design methods. Here, we developed a rati...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599006/ https://www.ncbi.nlm.nih.gov/pubmed/31253862 http://dx.doi.org/10.1038/s41598-019-44688-0 |