WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

Cancer cells secrete matrix metalloproteinases to remodel the extracellular matrix, which enables them to overcome tissue barriers and form metastases. The membrane-bound matrix metalloproteinase MT1-MMP (MMP14) is internalized by endocytosis and recycled in endosomal compartments. It is largely unk...

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Detalles Bibliográficos
Autores principales: Sneeggen, Marte, Pedersen, Nina Marie, Campsteijn, Coen, Haugsten, Ellen Margrethe, Stenmark, Harald, Schink, Kay Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599030/
https://www.ncbi.nlm.nih.gov/pubmed/31253801
http://dx.doi.org/10.1038/s41467-019-10794-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599030/
https://www.ncbi.nlm.nih.gov/pubmed/31253801
http://dx.doi.org/10.1038/s41467-019-10794-w

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