Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space

Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal muscle; MuRF1 null (KO) mice have shown protection in ground-based models of muscle atrophy. In contrast, MuRF1 KO mice s...

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Detalles Bibliográficos
Autores principales: Cadena, Samuel M., Zhang, Yunyu, Fang, Jian, Brachat, Sophie, Kuss, Pia, Giorgetti, Elisa, Stodieck, Louis S., Kneissel, Michaela, Glass, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599046/
https://www.ncbi.nlm.nih.gov/pubmed/31253821
http://dx.doi.org/10.1038/s41598-019-45821-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599046/
https://www.ncbi.nlm.nih.gov/pubmed/31253821
http://dx.doi.org/10.1038/s41598-019-45821-9

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